| 摘要 |
Octapeptide are described of the formula: <CHEM> wherein each A1 and A2, independently, is H, C1-12 alkyl, C7-10 phenylalkyl, R1CO (where R1 is C1-20 alkyl, C3-20 alkenyl, C3-20 alkinyl, phenyl, naphthyl, or C7-10 phenylalkyl), or R2OCO (where R2 is C1-10 alkyl or C7-10 phenylalkyl), provided that when one of A1 or A2 is R1CO or R2OCO, the other must be H; A3 is CH2-A6 (where A6 is pentafluoro, naphthyl, pyridyl, or phenyl which is optionally ring-substituted with a halogen, C1-3 alkyl, NO2, C1-3 alkoxy, NH2, or OH); A4 is o-m- or; more preferably, p substituted X-Phe (where X is a halogen, H, NO2, OH, NH2, or C1-3 alkyl), pentafluoroalanine, or naphthylalanine; and A5 is Thr, Ser, Phe, Val, or Ile; or a pharmaceutically acceptable salt thereof.
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