发明名称 |
ISOQUINOLINESULFONAMIDE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF |
摘要 |
<p>This invention relates to novel isoquinolinesulfonamide derivatives of Formula (I): <IMAGE> (I) wherein A is a C0-10 alkylene group or a C0-10 alkylene group having a C1-10 alkyl group, a phenyl group, a substituted phenyl group or a phenylalkyl group; R1 and R2 each is a hydrogen atom; or R1 and R2 are linked directly to form an ethylene group unsubstituted or substituted with a C1-4 alkyl group; R3 and R4 each is a hydrogen atom, a C1-6 alkyl group or linked directly to form a C2-6 alkylene group; and the pharmaceutically acceptable acid addition salt thereof, and to a process for preparing them. The isoquinoline derivatives possess a relaxatory action for vascular smooth muscle and action for increasing blood flow and are useful as a vasodilator and a hypotensor.</p> |
申请公布号 |
EP0109023(B1) |
申请公布日期 |
1987.03.25 |
申请号 |
EP19830111095 |
申请日期 |
1983.11.07 |
申请人 |
ASAHI KASEI KOGYO KABUSHIKI KAISHA;HIDAKA, HIROYOSHI |
发明人 |
HIDAKA, HIROYOSHI;SONE, TAKANORI |
分类号 |
A61K31/47;A61K31/472;A61P9/08;A61P9/12;C07D217/02;C07D401/12;(IPC1-7):C07D217/02;C07D401/14 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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