发明名称 |
alpha -Chlorinated carbonates |
摘要 |
The invention relates to new alpha -chlorinated carbonates characterized in that their formula is: <IMAGE> in which X is a fluorine, chlorine or bromine atom and R1 is different from the <IMAGE> group and represents; a substituted or non-substituted, saturated or unsaturated, aliphatic, araliphatic, primary, secondary, tertiary or cycloaliphatic radical. These alpha -chlorinated carbonates are prepared by the action of a compound of formula R1OH on a chloroformate of formula: <IMAGE> in a solvent medium in the presence of an acid scavenger which is added after the two preceding compounds. They are used to block the amine function of amino acids. The alpha -chlorinated carbonate and amino acid are reacted in a solvent medium at a temperature of -5 DEG to 100 DEG C. in the presence of an acid scavenger. Blocked amines are very useful in peptide synthesis.
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申请公布号 |
US4652665(A) |
申请公布日期 |
1987.03.24 |
申请号 |
US19850701429 |
申请日期 |
1985.02.14 |
申请人 |
SOCIETE NATIONALE DES POUDRES ET EXPLOSIFS |
发明人 |
BARCELO, GERARD;SENET, JEAN-PIERRE;SENNYEY, GERARD |
分类号 |
C07C69/96;C07B51/00;C07C68/00;C07C68/02;C07C227/14;C07C227/44;C07C229/00;C07C269/04;C07C271/02;C07D207/16;C07D209/20;C07D233/54;C07F7/08;(IPC1-7):C07C69/96 |
主分类号 |
C07C69/96 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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