Aziridine and phenethanolamine derivatives having antiobesity and anti-hyperglycaemic acitivity

摘要

Aziridine and phenethanolamine derivatives of formulae I and II-1 <IMAGE> I <IMAGE> II-1 wherein R1 and R2 are hydrogen or lower-alkyl; Z1 is phenyl or a phenyl group substituted in a defined manner; Z2 and Z21 are phenyl or thienyl substituted in a defined manner; and, n is an integer from 1-4. The disclosed compounds have catabolic activity and can be used for the treatment of obesity and/or of sugar illnesses. The compounds of formula I are obtained by dehydrating beta -aminoalcohols (e.g. those of formula II-1) which, in turn, can be prepared by adding amines to epoxides or by reducing corresponding iminoketones, iminoalcohols a-keto- beta -hydroxyamines or beta -ketoamines.