| 摘要 |
The title compds. are prepd. by reacting a (R)-6-fluoro- 4ureidochroman-4-carboxylic acid or (R)- and (RS)-6-fluoro-4- ureidochroman-4-carboxylic acid mixt. with potassium perman ganate in the presence of aq. solvent system i.e. 0.5-3 vol. % of acetic acid glacial at 10-70≦̸C and 3.0-7.0 of pH. The pH adjusted with HCl, sulfuric acid, nitric acid, acetic acid. Prepd. compds. are useful for intermediates of sorvinyl prodn.. For the treatment of diabetic complication, dose a diabetic patient with sorvinyl as an aldos- redn.-enzyme-inhibitor.
|
