Peptide derivatives, process for the production thereof and pharmaceutical compositions containing same.

摘要

New peptide derivatives represented by the following general formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="7" wi="32" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R, is a hydrophobic radical, R<Sub>2</Sub> is a hydrophilic rodical,
Pro is prolyl and Hyp is hydroxyprolyl show more powerful Inhibitory action against platelet agglutination than conventional drugs and have potential use as anti-agglutination agent. The peptide derivative can be prepared by condensing a peptide containing a hydrophobic radical with a carboxylic acid containing a hydrophilic radical.

The invention relates also to pharmaceutical compositions containing the new peptide derivatives as active ingredients.