| 摘要 |
A class of bicyclic benzenoid aminoalkylene ether and thioether compounds of the formula: wherein: a is 0, 1 or 2; b is 0 or 1; c is 1-b, 2-b or 3-b; d is 0 or 1; e is 2, 3 or 4; X is oxygen, sulfur, ; Z is -NHR4, CN or ; R1 is -NR2R3, ; R2 and R3 are each independently H or alkyl, or both together with he nitrogen to which they are attached form a 5, 6 or 7-membered ring which may include one to three additional hetero atoms of N, 0 or S; R4 is selected from the group consisting of H, R5 is H or lower alkyl; R6 is H or lower alkyl or R6 and R2 together are ethylene or propylene and form a 5- or 6-membered ring together with the nitrogens to which they are attached; R7 is hydrogen, lower alkyl, lower alkenyl, aryl, arloweralkyl, hydroxyloweralkyl, acyloxyloweralkyl, loweralkoxyloweralkyl, aryloxyalkyl, aroyloxyalkyl, aralkyloxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, hydroxy, alkoxy, alkylthio or halogen or NR8R9; R8 is hydrogen, lower alkyl, lower alkenyl or arloweralkyl; R9 is hydrogen, COR10, SO2R11 or ; R10 is hydrogen, lower alkyl, aryl, arloweralkyl, lower alkoxy, heteroaryl, or monocyclic heteroarylalkyl; R11 is lower alkyl or aryl; R12 is hydrogen, lower alkyl, cycloloweralkyl, aryl or arloweralkyl; R13 is halo, amino, nitro, cyano, hydroxy, lower alkyl, lower alkoxy, lower alkanoyl, cycloloweralkyl, mono or dilower alkyl amino, lower alkanoyl, lower alkanoyl amino, haloloweralkyl, aryl, mercapto, loweralkoxy carbonyl, carboxy, loweralkylthio, loweralkylsulfonyl, sulfamoyl, or lower alkyl sulfamoyl; R14 is SO2, SO, S or C=O; or a pharmaceutically acceptable salt thereof. The compounds of the invention are useful in the treatment of physiological disorders including gastrointestinal disoxders in humans and other mammals. |
