| 摘要 |
<p>Substituted phenylalkyl(piperazinyl or homopiperazinyl)-propyl-(ureas or thioureas) Compounds of formula I (I) (wherein R1, R2 and R3 are each independently hydrogen, lower alkyl, hydroxyl, lower alkoxy, lower alkanoyloxy, lower alkanoyl, halogen, nitro, cyano, lower alkoxycarbonyl, di(lower alkyl)amino, lower alkylthio or trihalomethyl; R4 is hydrogen, alkyl of 1 to 12 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, allyl, phenyl, or phenyl substituted by lower alkyl, halogen, lower alkoxy, carboxyl, lower alkoxycarbonyl, lowe alkoxyethoxycarbonyl, cyano, nitro, lower alkylthio, di(lower alkyl)aminoethoxycarbonyl, lower alkylsulfonyl, lower alkylsulfinyl, carbamyl, tetrazolyl, sulfamyl, hydroxyl or lower alkanoyl; n is 1, 2, 3 or 4; m is 0 or 1; p is 2, 3 or 4; and X is oxygen or sulfur); having activity as antihistamine or inhibitors of mediator release from basophils or mast cells.</p> |
