摘要 |
2-Amino-4-aminothienyl thiazole and derivs. of formula (I) and their acid-addn. salts are new. R=NH2, guanidino, mono- or di-alkylamino, alkenylamino, or PhNH or Ph2N (both opt. ring substd. by halogen, alkyl, CF3, alkoxy, NO2 or NH2) or acylamino; A=NH2, mono- or di-alkylamino, cyclic amino, alkanoylamino, NHCO(CH2)nNR1R2, NHCO(CH2)x(CHR4)y(CH2)zXR3 or NHCOR5; R1,R2= H or alkyl, or NR1R2=heterocyclic gp. n=0-3; R3=H, alkyl, akanoyl, mono- or di-alkylaminoalkyl or aryl, aralkyl or heteroaryl (all 3 opt. ring substd. by halogen, NH2, NO2, alkyl, alkoxy, mono- or di-alkylamino, mono- or dialkylaminoalkyl or cyclic aminoalkyl); X=O or S; R4=H or alkyl; x,y,z=0-3, provided that x+y+z=3 or less; R5=aryl, aralkyl or heteroaryl (all opt. ring substd. as defined above: Z=H or halogen, m=0-4.
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