| 摘要 |
New cepham sulphones of fomula(I) [R1=carboxylic acyl; R2=H, alkoxy or alkylthio; R3=removable ester-forming gp. were prepd. by reduction of corresp. 3-acetoxy-methyl-3-cephems. Thus, a corresp. 3- acetoxymethyl-3-cephem was reacted with activated Zn, Mg, activated Mg or amalgamated Mg in presence of a bound proton source in solvent at -30≦̸C to 30≦̸C to give cepham deriv. (II) [n=1 or 2 . (II) are intermediates in the prepn. of antibacterial cephalosporins, esp. the 1-oxides and 1-oxado-thiacepahlosporins.
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