| 摘要 |
Thioethers were prepd. by treating RSSiR1R2R3 (R=org. group; R1,R2,R3=C1-4 alkyl) with org. halides, sulfates, or sulfonates in the presence of hexamethylphosphoric triamide under neutral conditions in aprotic solvents. Thus, treating PhCH2Br in MeCN and hexamethylphosphoric triamide with PhSSiMe3 in MeCN(1.5 h, 50≦̸C) gave a 97% yield of PhCH2SPh. Among the other 24 thio ethers prepd. were; EtSPh, (PhS)2CH2, 4-ClC6H4SC6H4NO2-4,5-benzylthio-2methyl-1,3,4- thiadiazole, and 7-phenylacetamido-3-(4-chlorophenyl) thiomethyl-3- cephem-4-carboxylic acid 1-oxide.
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