4-(1H-INDOLYL-3-)-ALPHA-METHYL PIPERIDINE-1-ETHANOL DERIVATIVES, THEIR SALTS, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE AS MEDICINES

摘要

Novel 4-(1H-indol-3-yl)- alpha -methyl-piperidine-1-ethanol derivatives of the formula I wherein R is selected from the group consisting of hydrogen, halogen, alkyl and alkoxy of 1 to 5 carbon atoms, -NO2, -NH2, CF3- and CH3S-, R1 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, R2 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and -OH, Ar is selected from the group consisting of optionally substituted aryl and heteroaryl, the dotted line indicates the optional presence of a double bond and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable antagonistic properties toward calcium ion and antihypertensive activity and certain compounds possess alpha and/or beta -blocking properties.