Precursors and synthesis of methyl-9-oxo-11 alpha, 16-dihydroxy-16-vinyl-5-cis-13-trans prostadienoates.

摘要

Novel precursors for the synthesis of methyl-9-oxo-11 alpha , 16-dihydroxy-16-vinyl-5-cis-13-trans prostadienoates having the formula wherein R1 is H or C1-C4 alkyl; R2 is C1-C4 alkyl, R3 is H, C1-C4 trialkylsilyl or C1-C6 alkyl; X1 is halogen, cyano, C1-C4 alkoxycarbonyl, carboxy or tri (C1-C4 alkoxy)methyl; n is 2-4 inclusive; and P1 is H or a blocking or protective group; congeners and racemic mixture of these compounds and processes of synthesizing them.