The use of amphipathic molecules for radioimaging and therapy with conjugates of monoclonal or polyclonal antibodies.

摘要

Methods are disclosed for increasing the solubility of antibodies and their radioisotope toxin, or drug immunoconjugates and for reducing the nonspecific uptake of antibody, either conjugated or unconjugated, into the RES organs such as via Fc receptor-mediated mechanisms. The methods involve incubation of the reactive component with amphipathic molecules, such as an anionic detergent, to achieve the desired result. A preferred anionic detergent in this regard is sodium dodecylsulfate.