2-SUBSTITUTED QUINOLINE

摘要

Compounds having the formula: are selective antagonists of leukotrienes of D4. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents and may be made up into pharmaceutical compositions. In the formula R<1> is H, halogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, -CF3, -OR<2>, -SR<2>, -NR<2>R<2>, -CHO, -COOR<2>, -(C=0)R<2>, -C(OH)R<2>R<2>, -CN, -NO2, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, or substituted or unsubstituted phenethyl; R<2> is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, -CF3, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, or substituted or unsubstituted phenethyl; R<3> is -(A)m-(CR<2>=CR<2>)p-(CR<2>R<2>)m-Q; R<4> is H, halogen, -NO2, -CN, -OR<2>, -SR<2>, NR<2>R<2>, or C1-C8 alkyl; R<6> is H or C1-C4 alkyl; R<7> is A) a monocyclic or bicyclic heterocyclic radical containing from 3 to 12 nuclear carbon atoms and 1 or 2 nuclear heteroatoms selected from N and S with at least one being N, and with each ring in the heterocyclic radical being formed of 5 or 6 atoms, or B) the radical W-R<8>; R<8> contains up to 21 carbon atoms and is (1) a hydrocarbon radical or (2) an acyl radical of an organic acyclic or monocyclic carboxylic acid containing not more than 1 heteroatom in the ring; R<9> is -OR<1><0>, -SR<1><0>, or NR<1><0>R<1><0>; R<1><0> is H, C1-C6 alkyl, -(C=O)R<1><1>, unsubstituted phenyl or unsubstituted benzyl; R<1><1> is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, -CF3, or unsubstituted phenyl, benzyl, or phenethyl; m is 0-8; n is 1 or 2;