Drug dispensing wound dressing

摘要

The disclosed wound dressings have a drug dispersed throughout a polyurethane matrix that is the reaction product of: (A) An isocyante terminated prepolymer formed by reaction of isophorone diisocyanate and a macroglycol and (B) a monomer containing hydroxyl and vinyl groups. The reaction product is a vinyl terminated polyurethane oligomer which is liquid at room temperature and which may be readily admixed with a pharmacoactive substance and a photosensitizer, formed into a film and cured by exposure to UV light without release of heat. In the most preferred embodiments the foregoing oligomer is codissolved in an organic solvent with a polyurethane polymer which is the reaction product of: dicyclohexyl methane diisocyanate; a polytetramethylene ether polyol having a molecular weight in the range of 1000-3000 daltons; and 1,4-butane diol. That solution is then admixed with the pharmacoactive agent, formed into a film and cured.