| 摘要 |
The present invention provides compounds of formula (2): …<CHEM>… and their pharmaceutically acceptable salts which are useful as histamine H1-antagonists. In formula (2)… Hal is a halogen atom;… R<5> is an amino group or an pharmaceutically acceptable derivative thereof convertible in vivo to amino;… R<6> is a C1-3 alkylene group; and… R<7> is 3-pyridyl, N-oxo-3-pyridyl; 6-methyl-3-pyridyl; N-oxo-6-methyl-3-pyridyl; 6-hydroxymethyl-3-pyridyl; 4,6-dimethyl-3-pyridyl; N-oxo-4,6-dimethyl-3-pyridyl; 6-hydroxymethyl-4-methyl-3-pyridyl; 5,6-dimethyl-3-pyridyl; N-oxo-5,6-dimethyl-3-pyridyl; 6-hydroxy-methyl-5-methyl-3-pyridyl; 4-pyridyl or N-oxo-4-pyridyl. |
