SYNTHETIC PEPTIDE SPECIFIC ANTIGENIC DETERMINANT AND METHOD OF MANUFACTURING ANTIGENIC MATERIALS THEREFROM

摘要

A highly pure and specific synthetic peptide is manufactured by determining from a DNA sequence and then synthesizing a peptide which corresponds to a possible antigenic determinant, which may be known or unknown, of a natural antigenic protein and attaching the synthetic peptide to a carrier. This synthetic antigen may be used to prepare a vaccine which, when introduced into the host, initiates production in the host of antibodies to the natural protein or of cell mediated response to the natural protein, or both, the peptide constituting the specific antigenic determinant of the thus manufactured antigen.