| 摘要 |
NEW MATERIAL:Substituted phenoxypropylamide compound of formula I (Y is piperidino or 1-perhydroazepinyl; R is H or CH3; X is halogen; l is integer of 1-5). EXAMPLE:N-[4-{3-(piperidinomethyl)phenoxy}propyl]-2-chloroacetamide. USE:A histamine H2-receptor antagonistic agent useful as an antiulcer agent. An intermediate for novel anti-peptic ulcer. PREPARATION:The compound of formula I can be produced by reacting the compound of formula II with the compound of formula X'OC(CH2)lX(X' is halogen or OH) by conventional acylation reaction procedure. The compound is an anti-peptic ulcer agent having excellent properties compared with known drugs having similar activity and furthermore, it is useful especially as an intermediate for the novel substance of formula III (p is 0, 1 or 2; Z is group of formula IV-VI, etc.) which is an anti-peptic ulcer agent in itself. |
