发明名称 |
Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins. |
摘要 |
<p>This invention is directed to a formulation of cardiotonic phosphodiesterase inhibitors with a water-soluble vitamin, comprising a lyophilization step performed on a sulution of the complex in an aqueous/organic solvent system. The formulation results in a complex that has been found to have enhanced solubility (over the compound alone) in a parenterally or orally acceptable solvent, and the lyophilization process yields a product with superior stability permitting an extended shelf life.</p> |
申请公布号 |
EP0212647(A2) |
申请公布日期 |
1987.03.04 |
申请号 |
EP19860111663 |
申请日期 |
1986.08.22 |
申请人 |
SYNTEX (U.S.A.) INC. |
发明人 |
BENJAMIN, ERIC J.;VISOR, GARY C. |
分类号 |
A61K9/08;A61K31/505;A61K31/51;A61K45/06;A61P3/02;A61P9/04;A61P43/00 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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