PARAMAGNETIC COMPLEX SALTS, THEIR PREPARATION, AND THEIR USE IN NMR-DIAGNOSTICS

摘要

Preparations for influencing the relaxation times in NMR-diagnostics, comprising at least one physiologically compatible paramagnetic complex salt from aminopolycarboxylic acids having the formulae I to IV < IMG > (I) N-hydroxy-ethyl-N,N',N'-ethylene-diamine triacetic acid, < IMG > (II) N,N,N',N",N"-diethylene-triamine pentaacetic acid, HOH2C-CH2N(CH2COOH)2 (III) N-hydroxy-ethyl-imino diacetic acid, < IMG > (IV), wherein m represents the numbers 1 to 4, n represents the numbers 0 to 2, R1 represents a saturated or unsaturated hydrocarbon radical containing 1 to 4 hydrocarbon atoms or the group -CH2-COOH, or disphosphonic acids having the general formula V < IMG > (V), wherein R2 represents hydrogen, alkyl containing 1 to 4 carbon atoms, halogen, the hydroxy, amino or -CH2-COOH group and R3 represents hydrogen, alkyl containing 1 to 4 carbon atoms, the -CH2-COOH group or also halogen when R2 represents halogen, and from the ions of the lanthanide elements having the atomic numbers 57 to 70 or from the ions of the transition metals having the atomic numbers 21 to 29, 42 and 44 and, if desired, an inorganic base also methods for their preparation, and their use in a method of diagnosis using NMR.