发明名称 |
Method of continuous production of retroviruses (HTLV-III) from patients with AIDS and pre-AIDS |
摘要 |
A cell system is disclosed for the reproducible detection and isolation of human T-lymphotropic retroviruses (HTLV-family) with cytopathic effects (HTLV-III) from patients with the acquired immune deficiency syndrome (AIDS), pre-AIDS and in healthy carriers. One neoplastic aneuploid T-cell line derived from an adult with lymphoid leukemia, and termed HT, was susceptible to infection with the new variants of HTLV, which are transformed and providing T-cell populations which are highly susceptible and permissive from HTLV-III, and convenience for large scale production, isolation and biological detection of the virus.
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申请公布号 |
US4647773(A) |
申请公布日期 |
1987.03.03 |
申请号 |
US19840602946 |
申请日期 |
1984.04.23 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
GALLO, ROBERT C.;POPOVIC, MIKULAS |
分类号 |
G01N33/50;A61K39/21;A61P31/12;A61P31/18;C12N5/00;C12N5/09;C12N7/00;C12R1/91;C12R1/92;G01N33/569;(IPC1-7):C12N7/02 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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