发明名称 |
Process for preparing aminohydroxycephamcarboxylates |
摘要 |
A useful synthetic intermediate, 7-amino-3-acyloxycepham-4-carboxylic acid aralkyl ester, is prepared by reducing 7-amido-3-oxocepham-4-carboxylic acid aralkyl ester with alkali metal borohydride in a dry organic solvent at temperature lower than -20 DEG C. and then acylating the resulting 3-hydroxycepham compound with an acylating reagent to give 3-acyloxycepham compound, and then subjecting the 3-acyloxycepham compound to amide cleavage consisting of treatments (1) with a mixture of phosphorus pentachloride and aromatic base giving imino-chloride and (2) with alcohol for converting the latter into imino-ether and for subjecting the product to alcoholysis giving the objective compound.
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申请公布号 |
US4647658(A) |
申请公布日期 |
1987.03.03 |
申请号 |
US19850739302 |
申请日期 |
1985.05.29 |
申请人 |
SHIONOGI & CO., LTD. |
发明人 |
HAMASHIMA, YOSHIO;TAKAMI, FUMITAKA |
分类号 |
A61K31/545;C07D;C07D501/00;C07D501/04;C07D501/14;C07D501/16;C07D501/20;C07D501/59;(IPC1-7):C07D501/20 |
主分类号 |
A61K31/545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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