PROCESS FOR PRODUCING OF VINIL-TIO-ACETAMID-OXA-CEF-3-EM-CARBONIC ACID DERIVATES

摘要

NEW MATERIAL:The compound of fomula I (u, v and w are H or substituent group; x is halogen, trifluoromethyl, alkylthio or arylthio; y is H, light metal atom, or carboxy-protecting group; z is acyloxy or heterocyclicthio). EXAMPLE:7beta-Chlorovinylthioacetamido-7alpha-methoxy-3-[1-( hydroxyethyl )-5-tetrazolyl]-thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid diphenylmethyl ester. USE:An antibacterial agent. PROCESS:The compound of formula I can be prepared by reacting the amine of formula II or its reactive derivative with the vinylthioacetic acid of formula IIIor its reactive derivative.