Intermediates for preparing 1,2-dihydropyrido[3,4-b]-pyrazines

摘要

1,2-Dihydropyrido[3,4-b]pyrazines are provided which possess anticancer activity. The compounds have the structure: <IMAGE> I wherein Y is CH2 or N(CH3); R1 is a lower alkyl group; e.g., an alkyl group containing up to six carbon atoms such as methyl, ethyl, propyl, butyl, etc.; R2 is a member selected from the group consisting of hydrogen, CH3O or Cl; and R3 and R4 are either both hydrogen or one is hydrogen and the other is a lower alkyl group.