发明名称 |
ANTIVIRAL ACTIVITY AND RESOLUTION OF 2-HYDROXYMETHYL-5-(5-FLUOROCYTOSIN-1-YL)-1,3-OXATHIOLANE |
摘要 |
A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane, a pharmaceutically acceptable derivative thereof, including a 5' or N<4> alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier. A process for the resolution of a racemic mixture of nucleoside enantiomers is also disclosed that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of the enantiomers. |
申请公布号 |
WO9214743(A2) |
申请公布日期 |
1992.09.03 |
申请号 |
WO1992US01339 |
申请日期 |
1992.02.20 |
申请人 |
EMORY UNIVERSITY |
发明人 |
LIOTTA, DENNIS, C.;SCHINAZI, RAYMOND, F.;CHOI, WOO-BAEG |
分类号 |
A61K31/505;A61K;A61K31/39;A61K31/506;A61K31/513;A61K31/66;A61K31/70;A61P1/16;A61P31/12;A61P31/18;A61P37/04;C07D;C07D239/36;C07D327/04;C07D405/04;C07D411/04;C07F9/547;C07H5/00;C07H19/06;C07H19/10;C12P13/00;C12P17/16;C12P19/38;C12P41/00 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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