| 摘要 |
<p>It has now been found that a certain structually distinct class of substituted benzamides has useful pharmaceutically activity. For example the compounds of this class may be used in the treatment of disorders of the gastro-intestinal function. More specifically the majority of the compounds can be used to treat the disorder emesis, and some of the compounds can be used to treat other such disorders, for example retarded gastric emptying, dyspepsia, flatulence, oesophagal reflux and peptic ulcer. Additionally many of the compounds have a beneficial action on the central nervous system, such as antipsychotic activity. We have also found that some of the compounds may be used in the treatment of obesity, and some have antiarrhythmic activity. The compounds are of the formula (I): (I) wherein: R1 is a C1-6 alkoxy group; R2 and R3 are the same or different and are hydrogen, halogen, CF3, C2-7 acyl, C2-7 acylamino, or amino, aminocarbonyl or aminosulphone optionally substituted by one or two C1-6 alkyl groups, C1-6 alkylsulphone or nitro; R5 is hydrogen or C1-6 alkyl; R6 is C1-7 alkyl or a group -(CH2)sR7 where s is 0 to 2 and R7 is a C3-8 cycloalkyl group, or a group -(CH2)tR8 where t is 1 or 2 and R8 is C2-5 alkenyl or a phenyl group optionally substituted by one or two substituents selected from C1-6 alkyl, C1-4 alkoxy, trifluoromethyl and halogen; and n, p and q are independently 0 to 2.</p> |
