PROCESS FOR OBTAINING AMINATED DERIVATIVES OF PYRIDAZINE SUBSTITUTED IN 6 POSITION BY A HETEROCYCLE OR AN ALICYCLE

摘要

The present invention relates to a process for obtaining aminated derivatives of pyridazine of formula: (I) in which: - R1 designates a 2-thienyl, 3-thienyl or cyclohexyl group; - R2 represents a lower alkyl group (1 to 4 atoms of carbon), or an atom of hydrogen as well as the salts of said derivatives with the acids, comprising the steps of reacting a chlorinated derivative of formula in which R1 and R2 are as defined hereinabove, with an amine of formula: reaction being carried out in a solvent such as an alcohol, hot in the presence of a hydracid acceptor, and possibly of converting the derivative thus obtained into a pharmaceutically acceptable salt. The products have therapeutic application as antidepressants.