发明名称 |
Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof |
摘要 |
There is provided a novel and efficient stereoselective total synthesis of epipodophyllotoxin and related epipodophyllotoxin compounds of the general formula <IMAGE> wherein R1 and R2 each are independently hydrogen or (lower)alkoxy, or R1 and R2, taken together, is methylenedioxy; R4 and R6 each are independently hydrogen or (lower)alkoxy; and R5 is hydrogen or a phenol-protecting group; or an acid addition salt thereof. The present invention also provides novel intermediates and processes for the preparation of said intermediates, which are then converted into known antineoplastic agents.
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申请公布号 |
US4644072(A) |
申请公布日期 |
1987.02.17 |
申请号 |
US19850722932 |
申请日期 |
1985.04.12 |
申请人 |
BRISTOL-MYERS COMPANY |
发明人 |
VYAS, DOLATRAI M.;SKONEZNY, PAUL M. |
分类号 |
C07D263/60;C07C51/00;C07C51/347;C07C51/353;C07C51/367;C07C51/377;C07C62/32;C07C62/34;C07C62/36;C07C62/38;C07C67/00;C07C69/03;C07C69/74;C07C69/757;C07C69/76;C07C69/96;C07C229/46;C07C253/00;C07C255/47;C07C255/52;C07D261/20;C07D307/92;C07D317/70;C07D493/04;C07D498/04;C07H3/00;C07H17/04;(IPC1-7):C07D317/44 |
主分类号 |
C07D263/60 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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