| 摘要 |
A process for recovering a dipeptide derivative comprises admixing an aqueous mixture of a solid dipeptide ester derivative of the formula <IMAGE> (I) wherein R1 is a lower alkyl group, R2 is a side chain group of an amino acid, n is 1 or 2, X is a benzyloxycarbonyl group which can have a nuclear substituent and Y is a hydrogen ion or an ammonium derivative ion of the formula <IMAGE> (II) wherein R3 is a side chain group of an amino acid and R4 is a lower alkyl group with an organic solvent capable of forming a binary phase system with water; said solvent being present in an amount effective to obtain the transfer of said peptide in the form of a solid from the aqueous phase to the organic solvent phase, settling the resulting admixture to form (1) an organic solvent phase containing in a solid state a substantial amount of dipeptide derivative of the formula <IMAGE> (III) wherein R1, R2, n and X are as defined above and Z is a hydrogen ion or an ammonium derivative ion of the formula <IMAGE>(IV) wherein R3 and R4 are as defined above, and (2) an aqueous phase, separating the organic solvent phase from the aqueous phase, and recovering the dipeptide derivative from the organic solvent phase. |
