| 摘要 |
<p>Pyridazinone derivs. of formula (I) and their acid addition salts are new. In (I) A is CH2, CH2CH2 or CH=CH, the last two opt. bustd. by lower alkyl. B is oxo or 2H atoms. R1 is H, lower alkyl, lakanoyl, alkylsulphonyl or benzoyl (opt. substd. by 1 same or different halo or lower alkyl or alkoxy). R2 is H, alkyl (opt. substd. by carbamoyl, naphthyloxy or oxo), lower hydroxyalkyl or R6R7N (CH2)n. R6 and R7 are each H or lower alkyl, or together complete a heterocycle n=2 or 3. R4 is H, lower alkyl, hydroxymethyl or alkanoyloxymethyl. R5 is H or lower alkyl. R3 is H, or R3 plus either R4 or R5 make up a bond). (I) have platelet-aggregation inhibiting activity and are useful e.g. in cases of transitory ischaemic incidients, shock, myocardial infarct, thrombosis ek, and for patients with prosthetic cardiac values or arterial-venous shunts.</p> |
