PRODUCTION OF HUMAN M-CSF

摘要

PROBLEM TO BE SOLVED: To obtain human M-CSF useful as an agent for preventing and treating various infectious diseases and a therapeutic agent, etc., for myelogenic leukemia by culturing a host transformed by a recombinant vector containing a human M-CSF gene having a specific nucleic acid sequence. SOLUTION: A host (E. coli, etc.) transformed by a recombinant vector containing a human M-CSF gene having a nucleic acid sequence coding for a partial amino acid sequence containing either one from 33th Glu to 37th Glu of amino acid sequence of the formula (X is Tyr or Asp) as N-end amino acid and containing 185th Thr as C end amino acid is cultured to provide the objective human M-CSF produced in the cell of the transformer or outside the cell of the transformer.