Diastereomer salts of phenylalanine and N-acyl derivatives thereof and process for the separation of optically active phenylalanine and N-acyl derivatives thereof

摘要

PCT No. PCT/HU85/00012 Sec. 371 Date Nov. 18, 1985 Sec. 102(e) Date Nov. 18, 1985 PCT Filed Mar. 1, 1985 PCT Pub. No. WO85/03932 PCT Pub. Date Sep. 12, 1985.The present invention relates to the separation of optically active phenylalanine and N-acyl derivatives thereof and novel diastereomer salts of the said compounds. According to the invention a racemic compound of the formula <IMAGE> I is reacted with an optically active resolving agent of the formula <IMAGE> II in a polar solvent and/or a mixture of solvents comprising at least one apolar solvent and optionally an achiral acid or base, thereafter (a) when using the D-isomer of the resolving agent of the formula II, the crystalline diastereomer salt formed with the L-isomer of the compound of the formula I is separated, or (b) when using the L-isomer of the resolving agent of the formula II, the crystalline diastereomer salt formed with the D-isomer of the compound of the formula I is separated, and the enantiomers of the compound of the formula I from the diastereomer salt or the mother liquor are liberated by the aid of an achiral acid or base and the optically active product is separated in crystalline form.