Phosphorous containing enzyme inhibitors.

摘要

Dipeptides and amino acids of the formula A-E-G are disclosed wherein A is, e.g., hydrogen, or Ra-, RbCO or RbSO2- where Ra and Rb are e.g., alkyl, cycloalkyl, or aryl; <CHEM> wherein R<1> is, e.g., alkyl; n is 0, 1; R<2> is, e.g., hydrogen or alkyl; R<3> is OH, NH2, NHR3_a, NR3_aN3_b, OR3_c where R3_b, and R3_c are e.g., alkyl; R<4> is, e.g., hydrogen or alkyl R<6> is H or methyl; R<7> is, e.g., hydrogen or alkyl; R<8> is, e.g., hydrogen, methyl or cycloalkyl such that when R<8> is cyloalkyl, R<6> and R<7> are hydrogen; R<9> is, e.g., hydroxy. The compounds have enzyme inhibitor activity e.g., renin inhibition angiotensin converting enzyme inhibition.