发明名称 |
NUCLEIC ACIDS ENCODING CASPASE-8H AND CASPASE-8I |
摘要 |
The present invention relates to the discovery and characterization of two novel forms of Caspase-8. The first Caspase-8 of the invention, Caspase-8h, encodes a 220 amino acid polypeptide which includes two FADD death effector domains. The second caspase of the invention, Caspase-8i, encodes an 81 amino acid polypeptide having one FADD death effector domain. The invention encompasses nucleic acid molecules encoding Caspase-8h and Caspase-8i, vectors containing these nucleic acid molecules, cells harboring recombinant DNA encoding Caspase-8h and/or Caspase-8i, host fusion proteins which include Caspase-8h and/or Caspase-8i, transgenic animals which express Caspase-8h and/or Caspase-8i, therapeutic methods, purified Caspase-8h, purified Caspase-8i, therapeutic compounds and methods employing Caspase-8h and Caspase-8i, and screening methods employing Caspase-8h and Caspase-8i.
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申请公布号 |
WO9838200(A1) |
申请公布日期 |
1998.09.03 |
申请号 |
WO1998US03702 |
申请日期 |
1998.02.27 |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC. |
发明人 |
HUNTER, JOHN, J.;SHYJAN, ANDREW, W.;WONG, GRACE, H., W. |
分类号 |
A61K38/00;A61K48/00;C12N9/64;(IPC1-7):C07H19/00;C07H21/04;C12N15/64 |
主分类号 |
A61K38/00 |
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