Modified enzymes, production and use thereof.

摘要

The present invention provides a modified enzyme of the formula: <CHEM> wherein SOD is a manganese-containing superoxide dismutase produced by a microorganism of the genus Serratia; n and m are the same or different and each is equal to about 7 to 700; R<1> and R<2> are the same or different and each is a hydroxy-protecting group; and x is equal to about 1 to 30. The modified enzyme of the present invention shows increased antiinflammatory activity, is substantially free from immunogenicity and shows a prolonged half-life time and higher level in blood, hence it can advantageously be used as an antiinflammatory agent.