发明名称 |
Antitumor polypeptide and a method of preparing the same. |
摘要 |
<p>This invention relates to a novel anti-tumor polypeptide prepared by suspended-culture of human acute monocytic leukemia cells THP-1 under or after contact with a differentiation inducing agent. The novel anti-tumor polypeptide do not exhibit cytotoxicity against human normal cells but give cytotoxicity to human tumor cells Hela, KB and T-24 cells which is known to be insensitive to conventional TNF, and mouse tumor cells such as sarcoma 180 and L-1210. The antitumor polypeptides may be prepared by a non-expensive serum-free medium.</p> |
申请公布号 |
EP0210588(A2) |
申请公布日期 |
1987.02.04 |
申请号 |
EP19860110139 |
申请日期 |
1986.07.23 |
申请人 |
MIZUNO, DEN'ICHI;SOMA, GEN-ICHIRO |
发明人 |
SOMA, GEN-ICHIRO;MIZUNO, DEN'ICHI;SHIBAI, HIROSHI |
分类号 |
A61K35/12;A61K38/00;A61K38/16;A61P35/00;C07K1/00;C07K7/00;C07K14/52;C07K14/525;C12P21/02;C12R1/91;(IPC1-7):C07K7/00;A61K37/02 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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