The synthesis of cyclopropane amino acids and peptides.

摘要

Cyclopropane ("cyclopropyl") amino acids and peptides containing at least one cyclopropyl amino acid are disclosed. The processes for synthesizing cyclopropyl amino acids and peptides containing at least one cyclopropyl amino acid are also disclosed. Cyclopropyl amino acids are useful as enzyme inhibitors and as substitutes for natural amino acids in peptide hormones such as regulators of bodily functions to enhance bioactivity, to stabilize the peptide into which it is incorporated to cleavage by enzymes and to convert such peptides into enzyme inhibitors. Specific dipeptides NABLA Asp - Phe.OCH3 or Asp- NABLA -Phe.OCH3 or NABLA Asp- NABLA -Phe.OCH3 are described as a stabilized peptide sweetener for foods and beverages. Methods for synethesis of the cyclopropyl-amino acids, the acids themselves, peptides where the acids have been inserted and food and drug products employing those peptides are illustrated.