| 摘要 |
New carboxylic acide derivatives having general formula (I) in which R1 is a possibly substituted aryl or aryloxy residue; R2 is hydrogen, a lower alkyl residue or the group R1-A-, as well as in the case where X represents the cyano group, an acylamino or amino group; A is a group of straight-chain or branched-chain, saturated or unsaturated alkyl group with 3 to 8 carbon atoms, which has a chain length of at least 3 carbon atoms; X represents the cyano group or a group of the formula -B-R3 or -D-NR4R5, in which B is O, S, SO, SO2, O(CO), OSO2, NHCO, NHSO2 or CO; D represents a valency dash, SO2 or CO; R3 is an alkyl, trifluoromethyl, cycloalkyl, aralkyl-, aralkenyl- or aryl group, in which the respective aryl residue can possibly be substituted; R4 is hydrogen, a lower alkyl residue, a possibly substituted aryl or aralkyl residue; R5 is hydrogen, a lower alkyl residue or R4 and R5 together are an alkyl chain with 4 to 6 carbon atoms which may be interrupted by O, S or NR6, and R6 is hydrogen, a lower alkyl residue or possibly a substituted phenyl or benzyl residue. Also described are their physiologically neutral salts, esters, amides and nitriles provided that in the case where: a) A is an alkyl group with 3 carbon atoms; a1) in all cases the aryl residue of the group R1 is not the unsubstituted phenyl residue and a2) X may not represent the groups -CN, NHCOR3 and NR4R5; b) where X is a residue of the formula -SCH3, R2 may not represent methyl; c) where X is the -NH2 or -NHCOCH3 group R1A- may not represent 4-phenylbutyl or 4-(4-methoxyphenyl)butyl; d) where X is the 2,4-dinitrophenyl group, R1A may not represent 4-phenylbutyl or 5-phenylpentyl; e) where X is the -COCH3 group, R1A may not represent 3-(2-chlorphenyl)propyl or 5-(4-methoxyphenyl)-pentyl. These compounds are used as medicines for lowering the sugar-level in the blood. |
