发明名称 |
Monoclonal antibodies to human plasma prekallikrein and methods of preparing and using same. |
摘要 |
<p>Four novel cell lines, ATCC #HB-8862 through ATCC #HB-8865 produce monoclonal antibody to human plasma prekallikrein. At least three of the antibodies also recognize plasma kallikrein, specifically the heavy chain thereof, and kallikrein-Cl-inhibitor complex. The antibodies do not cross-react with tissue kallikrein. The hybridomas are formed by fusing spleen cells from immunized BALB/c AnSkh mice with SP2/O-Agl4 myeloma cells. Diagnostic, therapeutic and biochemical uses of the monoclonal antibodies are provided.</p> |
申请公布号 |
EP0210029(A2) |
申请公布日期 |
1987.01.28 |
申请号 |
EP19860305373 |
申请日期 |
1986.07.14 |
申请人 |
TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
VELOSO, DULCE C.;COLMAN, ROBERT W. |
分类号 |
A61K38/00;C07K16/40 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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