发明名称 Monobasic disobutamide derivatives
摘要 Compositions of matter are disclosed of compounds of the formula <IMAGE> and the pharmaceutically acceptable acid addition salts thereof wherein X represents a halo, lower alkyl, hydrogen, trifluoromethyl, phenyl, or lower alkoxy substituent; Y represents -CN, -CONH2, -CON(R1)2 or -CO2R1 where R1 is a lower alkyl; m is the integer 1 or 2 and n is an integer from 1 to 3 inclusive; R2 represents lower alkyl; R3 represents lower alkyl or acetyl, aroyl, phenacetyl or trifluoracetyl; A, B, and D are carbonyl or methylene such that when one of A, B, or D is carbonyl, the others are methylene and R3 is lower alkyl, whereas when R3 is acetyl, aroyl, phenacetyl or trifluoroacetyl, A, B, and D are methylene. These compounds have utility as antiarrhythmic agents.
申请公布号 US4639524(A) 申请公布日期 1987.01.27
申请号 US19840628933 申请日期 1984.07.09
申请人 G. D. SEARLE & CO. 发明人 DESAI, BIPINCHANDRA N.;CHORVAT, ROBERT J.;RORIG, KURT J.
分类号 A61K31/40;A61K31/4015;A61K31/445;A61P9/06;C07D207/26;C07D207/27;C07D295/14;C07D295/145;C07D295/18;C07D295/185;(IPC1-7):C07D207/04;C07D211/06 主分类号 A61K31/40
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