| 摘要 |
<p>Novel thiopyranopyrimidine compounds and the pharmaceutically acceptable acid addition salts thereof having excellent hypoglycemic activity, platelet aggretation inhibitory activity, antihistamine activity and anti-allergy activity useful for prevention and treatment of various disorders caused by diabetes, allergy and the like are disclosed The novel thiopyranopyrimidine compounds are represented by the general formula (I) < IMG > (I) wherein R1 represents an amino group, a methylamino group, a hydroxyethylamino group, a pyrrolidino group, a morpholino group, a piperazino group or an N-substituted piperazino group, and R2 represents a methylamino group, a dimethylamino group, a piperazino group, an N-substituted piperazino group, a pyrrolidino group, a piperidino group or a morpholino group, said N-substituted piperazino group selected from the group consisting of N-alkylpiperazino group having 1 to 4 carbon atoms in the alkyl moiety, an N-benzyl-piperazino group, an N-formylpiperazino group and an N-(halo-benzyl) piperazino group wherein the halogen is selected from the group consisting of chlorine and bromine.</p> |
