POLYETHYLENE GLYCOL (PEG) POLYMERS FOR THE PROMOTION OF ANGIOGENESIS

摘要

Novel methods and compositions for stimulating angiogenesis, particularly at regions of myocardial and peripheral tissue ischemia are disclosed. Angiogenesis is promoted or enhanced by contacting a polyethylene glycol (PEG) polymer, such as a PEG mono-, di-, tri-, or tetraacrylate containing a photoinitator (eosin Y) and a radical generator (triethanolamine) and a reaction accelerator (n-vinyl pyrrolidine), with an area of tissue ischemia. The PEG polymer can be applied alone or in conjunction with angiogenic proteins or genes encoding angiogenic proteins.