BIOENGINEERED VEHICLES FOR TARGETED NUCLEIC ACID DELIVERY

摘要

There is disclosed a gene-delivery compound comprising: a) a single-chain binding polypeptide having at least one effector segment which includes at least one cysteinyl residue; and b) a nucleic acid-binding moiety which is coupled to the polypeptide via the cysteinyl residue. There is disclosed also a gene-delivery compound comprising: a) a single-chain, binding polypeptide having at least one effector segment which includes at least one cysteinyl residue; b) a lipid-associating moiety which is coupled to the polypeptide via the cysteinyl residue. Additionally disclosed are compositions comprising the above-mentioned compounds and a nucleic acid.