A process for preparing a finely divided preparation of a drug substance comprising wet milling a suspension of the drug substance in a mill having at least one chamber and agitation means, said chamber(s) and/or said agitation means comprising nylon, wherein the nylon comprises one or more internal lubricants results in finely divided preparations of a drug substance in which the level of grinding media contamination and process contamination are reduced.
申请公布号
WO0200196(A2)
申请公布日期
2002.01.03
申请号
WO2001EP07085
申请日期
2001.06.22
申请人
SMITHKLINE BEECHAM P.L.C.;HOLLAND, SIMON, JOSEPH;KNIGHT, WENDY, ANNE;LEONARD, GRAHAM, STANLEY
发明人
HOLLAND, SIMON, JOSEPH;KNIGHT, WENDY, ANNE;LEONARD, GRAHAM, STANLEY