| 摘要 |
PURPOSE:A pharmaceutical composition, containing an antibiotic substance and a phospholipid and capable of improving the absorbability of the antibiotic substance. CONSTITUTION:A pharmaceutical composition obtained by incorporating an antibiotic substance, preferably antimicrobial antibiotic substance, e.g. cephem phase substance such as cephaloridine, penicillin based substance such as benzylpenicillin, aminoglucoside based substance such as kanamycin, macrolide based substance such as erythromycin, etc., with a phospholipid, e.g. phosphatidyl choline, phosphatidyl ethanolamine, soybean lecithin, egg yolk lecithin, etc., at 100:10-1,000, preferably 50-800 weight ratio of the former to the latter. The resultant composition is capable of enhancing the stabilization and absorbability, particularly absorbability in digestive tracts, rectum and skin, and the synergistic effect of antibiotic substance absorption is observed by incorporation of a peripheral vasodilator therewith. The dose thereof is 1-500mg/day administered once or divided in several portions. |
