Phospholipid analogs useful as paf synthesis inhibitors.

摘要

There are disclosed phospholipid analogs having the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="27" wi="45" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein:
<UnorderedLists id="ula01" listStyle="none"><ListItem>Y represents, e.g., -O;</ListItem><ListItem>R represents, e.g., -(CH<Sub>2</Sub>)<Sub>15</Sub>CH<Sub>3</Sub>;</ListItem><ListItem>Z represents, e.g.,
<Chemistry id="chema02" num="0002"><Image id="ia02" he="14" wi="28" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry></ListItem><ListItem>X is, e.g., trimethylamine;</ListItem><ListItem>R<Sup>2</Sup> and R<Sup>3</Sup> can be the same or different and are independently, e.g.,
<UnorderedLists id="ula02" listStyle="none"><ListItem>(a) hydrogen;</ListItem><ListItem>(b) hydroxy;</ListItem><ListItem>(c) unsaturated or saturated, unsubstituted or substituted C<Sub>1</Sub>-C<Sub>4</Sub> alkyl group wherein the substituents are hydroxy, acetyloxy, sulfhydryl, fluoro;</ListItem><ListItem>(d) azido;</ListItem><ListItem>(e) amido;</ListItem><ListItem>(f) acetamido;</ListItem></UnorderedLists></ListItem><ListItem>m is, e.g., 1; and</ListItem><ListItem>n is, e.g., 2.</ListItem></UnorderedLists>

These compounds inhibit PAF (platelet-activating factor) biosynthesis and are thereby useful In the treatment of various diseases or disorders mediated by the PAF such as, for example, pain, fever, inflammation, cardiovascular disorder, asthma, lung edema, allergic disorders, skin diseases, psoriasis, and adult respiratory distress syndrome.