| 摘要 |
There is disclosed an improved process for producing a concentrate containing coagulation factors VII and VIIa in relatively high purity by contacting an aqueous preparation containing factors VII and VIIa with a divalent metal salt adsorbent having selective affinity for calcium-binding coagulation factors and eluting the coagulation factors therefrom, and contacting the eluate with an anionic exchange resin and selectively eluting coagulation factors VII and VIIa therefrom by step or gradient elution techniques to obtain factors VII and VIIa in high yield, free of other coagulation factors and other proteins. In one embodiment of this invention Cohn Effluent I may be used as the source of factors VII and VIIa.
|
