发明名称 Förfarande för framställning av 6- - substituerade penicillansyraderi vat och såsom mellanprodukter användbara 6-perfluoralkylsulfonyloxipe nicillansyraderivat.
摘要 <p>6-Alpha and 6-beta-substituted penicillanic acid derivatives of the formula: <IMAGE> (I) wherein R is H or a conventional penicillin carboxy protecting group or an ester forming residue readily hydrolyzable in vivo and R1 is a perhaloalkyl group of from 1 to 4 carbon atoms wherein the halogen atoms are fluoro or chloro, undergo SN2 nucleophilic displacement with halide or azide ions with inversion of configuration at C-6 to yield the corresponding 6-beta or 6-alpha-halo- or azido-substituted product.</p>
申请公布号 FI71562(C) 申请公布日期 1987.01.19
申请号 FI19800001581 申请日期 1980.05.15
申请人 PFIZER CORPORATION, 发明人 KEMP,JOHN EDWARD GLYN
分类号 C07F7/08;C07D499/00;C07D499/10;C07D499/32;C07D499/86;C07D499/87;C07D499/897;(IPC1-7):C07D499/00;C07D499/02 主分类号 C07F7/08
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