发明名称 |
Förfarande för framställning av 6- - substituerade penicillansyraderi vat och såsom mellanprodukter användbara 6-perfluoralkylsulfonyloxipe nicillansyraderivat. |
摘要 |
<p>6-Alpha and 6-beta-substituted penicillanic acid derivatives of the formula: <IMAGE> (I) wherein R is H or a conventional penicillin carboxy protecting group or an ester forming residue readily hydrolyzable in vivo and R1 is a perhaloalkyl group of from 1 to 4 carbon atoms wherein the halogen atoms are fluoro or chloro, undergo SN2 nucleophilic displacement with halide or azide ions with inversion of configuration at C-6 to yield the corresponding 6-beta or 6-alpha-halo- or azido-substituted product.</p> |
申请公布号 |
FI71562(C) |
申请公布日期 |
1987.01.19 |
申请号 |
FI19800001581 |
申请日期 |
1980.05.15 |
申请人 |
PFIZER CORPORATION, |
发明人 |
KEMP,JOHN EDWARD GLYN |
分类号 |
C07F7/08;C07D499/00;C07D499/10;C07D499/32;C07D499/86;C07D499/87;C07D499/897;(IPC1-7):C07D499/00;C07D499/02 |
主分类号 |
C07F7/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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