NEOCARZINOSTATIN COMPLEXES, A METHOD FOR PRODUCING THE SAME, AND AN ANTITUMOR AGENT CONTAINING SAID COMPLEXES AS AN ACTIVE COMPONENT

摘要

Novel neocarzinostatin anticancer agents have the formula: (SMA)-(NCS) wherein (NCS) is a neocarzinostatin residue, n is an integer ranging from 1 to 35, and (SMA) comprises the residue of a half-esterified styrene-maleic acid copolymer having an average molecular weight of from 1,000 to 10,000, said half-esterified styrene-maleic acid copolymer comprising (i) styrene residues, (ii) maleic acid residues covalently bonded to (NCS), (iii) free maleic acid residues, and (iv) half-esterified maleic acid residues, and further wherein the total amount of said residues (ii) and (iii) ranges from an average of 0.1 per molecule to 60 mole % of said (SMA).